In the hippocampal cell portion of the study, the researchers observed that EPA or DHA prevented increased cell death and decreased neurogenesis in the hippocampal cells. They found that this was due to new lipid mediators being formed in the brain.
And in the patient study, supplementing with the same omega-3s was linked to a reduction in depressive symptoms – an average reduction of 64% for EPA and 71% for DHA, to be precise.
As the first author of the study, Alessandra Borsini, Ph.D. states in a press release, "Our study has provided exciting new insights into how omega-3s produce anti-inflammatory effects that improve depression," adding that now that the mechanism behind those effects is understood, they are "developing." of potential new treatments for depression with omega-3 polyunsaturated fatty acids. "